The Typhoid IgG/IgM One Step Rapid Test Device is a lateral flow chromatographic immunoassay. The test cassette consists of: 1) a burgundy colored conjugate pad containing recombinant S. Typhoid H antigen and O antigen conjugated with colloid gold (Typhoid conjugates) and rabbit IgG-gold conjugates, 2) a nitrocellulose membrane strip containing two test bands (T1 and T2 bands) and a control band (C band). The T1 band is pre-coated with monoclonal anti-human IgM for the detection of IgM anti-S. Typhi, T2 band is pre-coated with reagents for the detection of IgG anti-S. Typhi, and the C band is pre-coated with goat anti rabbit IgG.